業績紹介

山崎 正和 (Masakazu Yamazaki)

原著論文

  • Mauri F., Reichardt I., Mummery-Widmer JL., Yamazaki M., Knoblich JA. (2014) The Conserved Discs-large Binding Partner Banderuola Regulates Asymmetric Cell Division in Drosophila. Curr. Biol. 24, 1811-1825.
  • Ayukawa T., Akiyama M., Mummery-Widmer JL., Stoeger T., Sasaki J., Knoblich JA., Senoo H., Sasaki T., Yamazaki M. (2014) Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 8(2):610-621.
  • Yamazaki M., Yamauchi Y., Goshima Y., Kanaho Y. (2013) Phosphatidylinositol 4-phosphate 5-kinase β regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons. Neurosci Lett. 547:59-64.
  • Takasuga S., Horie Y., Sasaki J., Sun-Wada GH., Kawamura N., Iizuka R., Mizuno K., Eguchi S., Kofuji S., Kimura H., Yamazaki M., Horie C., Odanaga E., Sato Y., Chida S., Kontani K., Harada A., Katada T., Suzuki A., Wada Y., Ohnishi H., Sasaki T. (2013) Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc. Natl. Acad. Sci. 110, 1726-1731.
  • Watanabe H., Hongu T., Yamazaki M., Kanaho Y. (2011) Phospholipase D2 activation by p38 MAP kinase is involved in neurite outgrowth. Biochem. Biophys. Res. Commun. 413, 288-293.
  • Sasaki J., Kofuji S., Itoh R., Momiyama T., Takayama K., Murakami H., Chida S., Tsuya Y., Takasuga S., Eguchi S., Asanuma K., Horie Y., Miura K., Davis M., Mitchell C., Yamazaki M., Hirai H., Takenawa T., Suzuki A., Sasaki T. (2010) The PtdIns(3,4)P2-phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature 465, 497-501.
  • *Mummery-Widmer J. L., *Yamazaki M. (*co-first author), Stoeger T., Novatchkova M., Chen D., Dietzl G., Dickson B. J., Knoblich J. A. (2009) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi.  Nature (Article) 458, 987-992.
  • Nakano-Kobayashi A., Yamazaki M., Unoki T., Hongu T., Murata C., Taguchi R., Katada T., Frohman M. A., Yokozeki T., Kanaho Y. (2007) Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis. EMBO J. 26, 1105-1116.
  • Nishio M., Watanabe K., Sasaki J., Taya C., Takasuga S., Iizuka R., Balla T., Yamazaki M., Watanabe H., Itoh R., Kuroda S., Horie Y., Förster I., Mak T. W., Yonekawa H., Penninger J. M., Kanaho Y., Suzuki A., Sasaki T. (2007) Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat. Cell Biol. 9, 36-44.
  • *Miyazaki H., *Yamazaki M. (*co-first author), Watanabe H., Maehama T., Yokozeki T., Kanaho Y. (2005) The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. FEBS Lett. 579, 6834-6838.
  • Su W., Chardin P., Yamazaki M., Kanaho Y., Du G. (2005) RhoA-mediated Phospholipase D1 signaling is not required for the formation of stress fibers and focal adhesions. Cell Signal. 18, 469-478.
  • Sasaki J., Sasaki T., Yamazaki M., Matsuoka K., Taya C., Shitara H., Takasuga S., Nishio M., Mizuno K., Wada T., Miyazaki H., Watanabe H., Iizuka R., Kubo S., Murata S., Chiba T., Maehama T., Hamada K., Kishimoto H., Frohman M. A., Tanaka K., Penninger J. M., Yonekawa H., Suzuki A., Kanaho Y. (2005) Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I alpha. J. Exp. Med. 201, 859-70.
  • Watanabe H., Yokozeki T., Yamazaki M., Miyazaki H., Sasaki T., Maehama T., Itoh K., Frohman M. A., Kanaho Y. (2004) Essential role for phospholipase D2 activation downstream of ERK MAP kinase in NGF-stimulated neurite outgrowth from PC12 cells. J. Biol. Chem. 279, 37870-37877.
  • Watanabe H., Yamazaki M., Miyazaki H., Itoh K., Sasaki T., Maehama T., Frohman M. A., Kanaho Y. (2004) Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons. J. Neurochem. 89, 142-151.
  • Nogami M., Yamazaki M., Watanabe H., Okabayashi Y., Kido Y., Kasuga M., Sasaki T., Maehama T., Kanaho Y. (2003) Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase Cg1 for membrane ruffle formation. FEBS Lett. 536, 71-76.
  • Yamazaki M., Miyazaki H., Watanabe H., Sasaki T., Maehama T., Frohman M. A., Kanaho Y. (2002) Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J. Biol. Chem. 277, 17226-17230.
  • Zhang Y., Redina O., Altshuller Y. M., Yamazaki M., Ramos J., Chneiweiss H., Kanaho Y., Frohman M. A. (2000) Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them. J. Biol. Chem. 275, 35224-35232.
  • Honda A., Nogami M., Yokozeki T., Yamazaki M., Nakamura H., Watanabe H., Kawamoto K., Nakayama K., Morris A. J., Frohman M. A., Kanaho Y. (1999) Phosphatidylinositol 4-phosphate 5-kinase a is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99, 521-532.
  • Kamei D., Tsuchiya N., Yamazaki M., Meguro H., Yamada M. (1999) Two forms of expression and genomic structure of the human heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL). Gene 228, 13-22.
  • Yamazaki M., Zhang Y., Watanabe H., Yokozeki T., Ohno S., Kaibuchi K., Shibata H., Mukai H., Ono Y., Frohman M. A., Kanaho Y. (1999) Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J. Biol. Chem. 274, 6035-6038.

総説(欧文)

  • Sasaki T., Takasuga S., Sasaki J., Kofuji S., Eguchi S., Yamazaki M., Suzuki A. (2009) Mammalian phosphoinositide kinase and phosphatases. Prog. Lipid Res. 48, 307-343.

  • Kanaho Y., Miyazaki H., Yamazaki M. (2003) Activation of PI(4)P 5-kinase by small G proteins. Adv. Enzyme Regul. 43, 107-119.

総説(邦文)

  • 山崎正和 (2010) 組織特異的ゲノムワイドRNAi スクリーニングによるNotchシグナル伝達系の解析. 蛋白質核酸酵素. 55, 26-33.

  • 山崎正和, 篠田陽子, 平林義雄 (2005) 軸索ガイダンス. 糖鎖科学の新展開. 216-223.

  • 佐々木雄彦, 佐々木純子, 山崎正和, 鈴木聡, 金保安則 (2005) ホスファチジルイノシトール4,5-二リン酸のコンパートメント化. 細胞工学. 24, 607-611. 

  • 金保安則, 佐々木純子, 佐々木雄彦, 宮崎秀幸, 中野亜希子, 横関健昭, 山崎正和 (2005) ホスファチジルイノシトール4-リン酸5-キナーゼと細胞膜ダイナミクス. 実験医学増刊. 23, 925-932. 

  • 金保安則, 佐々木純子, 佐々木雄彦, 山崎正和 (2005) ホスファチジルイノシトール4-リン酸5-キナーゼのアイソザイム特異的な生理機能. 細胞工学. 24, 386-391. 

  • 金保安則, 宮崎秀之, 中野亜希子, 山崎正和 (2003) ホスファチジルイノシトール4-リン酸5-キナーゼの活性調節機構と生理機能. 細胞工学. 22, 1360-1365. 

中西 広樹 (Hiroki Nakanishi)

原著論文

  • Abe Y., Honsho M., Nakanishi H., Taguchi R., Fujiki Y. (2014) Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency. Biochim Biophys Acta. 1841(4):610-9.
  • Hama K., Nagai T., Nishizawa C., Ikeda K., Morita M., Satoh N., Nakanishi H., Imanaka T., Shimozawa N., Taguchi R., Inoue K., Yokoyama K. (2013) Molecular species of phospholipids with very long chain fatty acids in skin fibroblasts of Zellweger syndrome. Lipids 48, 1253-1267.
  • Miki Y., Yamamoto K., Taketomi Y., Sato H., Shimo K., Kobayashi T., Ishikawa Y., Ishii T., Nakanishi H., Ikeda K., Taguchi R., Kabashima K., Arita M., Arai H., Lambeau G., Bollinger JM., Hara S., Gelb MH., Murakami M. (2013) Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. J. Exp. Med. 210, 1217-1234.
  • Tajima Y., Ishikawa M., Maekawa K., Murayama M., Senoo Y., Nishimaki-Mogami T., Nakanishi H., Ikeda K., Arita M., Taguchi R., Okuno A., Mikawa R., Niida S., Takikawa O., Saito Y. (2013) Lipidomic analysis of brain tissues and plasma in a mouse model expressingmutated human amyloid precursor protein/tau for Alzheimer’s disease. Lipids Health Dis. 12, 68.
  • Morita M., Kuba K., Ichikawa A., Nakayama M., Katahira J., Iwamoto R., Watanebe T., Sakabe S., Daidoji T., Nakamura S., Kadowaki A., Ohto T., Nakanishi H., Taguchi R., Nakaya T., Murakami M., Yoneda Y., Arai H., Kawaoka Y., Penninger JM., Arita M., Imai Y. (2013). The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza. Cell 153, 1-14.
  • Maekawa K., Hirayama A., Iwata Y., Tajima Y., Nishimaki-Mogami T., Sugawara S., Ueno N., Abe H., Ishikawa M., Murayama M., Matsuzawa Y., Nakanishi H., Ikeda K., Arita M., Taguchi R., Minamino N., Wakabayashi S., Soga T., Saito Y. (2013). Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy. J. Mol. Cell Cardiol. 59C, 76-85.
  • Yoshizawa T., Sakurai T., Kamiyoshi A., Ichikawa-Shindo Y., Kawate H., Iesato Y., Koyama T., Uetake R., Yang L., Yamauchi A., Tanaka M., Toriyama Y., Igarashi K., Nakada T., Kashihara T., Yamada M., Kawakami H., Nakanishi H., Taguchi R., Nakanishi T., Akazawa H., Shindo T. (2013). Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Hypertension 61, 341-351.
  • Isobe Y., Arita M., Matsueda S., Iwamoto R., Fujihara T., Nakanishi H., Taguchi R., Masuda K., Sasaki K., Urabe D., Inoue M., Arai H. (2012) Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid. J. Biol. Chem. 287, 10525-10534.
  • Imae R., Inoue T., Nakasaki Y., Uchida Y., Ohba Y., Kono N., Nakanishi H., Sasaki T., Mitani S., Arai H. (2012) LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. J. Lipid Res. 53, 335-347.
  • Arimitsu N., Kogure T., Baba T., Nakao K., Hamamoto H., Sekimizu K., Yamamoto A., Nakanishi H., Taguchi R., Tagaya M., Tani K. (2011) p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis. FEBS Lett. 585, 2171-2176.
  • Yamamoto K., Taketomi Y., Isogai Y., Miki Y., Sato H., Masuda S., Nishito Y., Morioka K., Ishimoto Y., Suzuki N., Yokota Y., Hanasaki K., Ishikawa Y., Ishii T., Kobayashi T., Fukami K., Ikeda K., Nakanishi H., Taguchi R., Murakami M. (2011) Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. J. Biol. Chem. 286, 11616-11631.
  • Roy M. C., Nakanishi H., Takahashi K., Nakanishi S., Kajihara S., Hayasaka T., Setou M., Ogawa K., Taguchi R., Naito T. (2011) Salamander retina phospholipids and their localization by MALDI imaging mass spectrometry at cellular size resolution. J. Lipid Res. 52, 463-470.
  • Yamada T., Tani Y., Nakanishi H., Taguchi R., Arita M., Arai H. (2011) Eosinophils promote resolution of acute peritonitis by producing pro-resolving mediators in mice. FASEB J. 25, 561-568.
  • Ikeda K., Mutoh M., Teraoka N., Nakanishi H., Wakabayashi K., Taguchi R. (2011) Increase of oxidant-related triglycerides and phosphatidylcholines in serum and small intestinal mucosa during development of intestinal polyp formation in Min mice. Cancer Sci. 102, 79-87.
  • Horai H., Arita M., Kanaya S., Nihei Y., Ikeda T., Suwa K., Ojima Y., Tanaka K., Tanaka S., Aoshima K., Oda Y., Kakazu Y., Kusano M., Tohge T., Matsuda F., Sawada Y., Hirai M. Y., Nakanishi H., Ikeda K., Akimoto N., Maoka T., Takahashi H., Ara T., Sakurai N., Suzuki H., Shibata D., Neumann S., Iida T., Tanaka K., Funatsu K., Matsuura F., Soga T., Taguchi R., Saito K., Nishioka T. (2010) MassBank: a public repository for sharing mass spectral data for life sciences. J. Mass Spectrom. 45, 703-714.
  • Sato H., Taketomi Y., Isogai Y., Miki Y., Yamamoto K., Masuda S., Hosono T., Arata S., Ishikawa Y., Ishii T., Kobayashi T., Nakanishi H., Ikeda K., Taguchi R., Hara S., Kudo I., Murakami M. (2010) Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J. Clin. Invest. 120, 1400-1414.
  • Seki H., Fukunaga K., Arita M., Arai H., Nakanishi H., Taguchi R., Miyasho T., Takamiya R., Asano K., Ishizaka A., Takeda J., Levy B. D. (2010) The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury. J. Immunol. 184, 836-843.
  • Nakanishi H., Iida Y., Shimizu T., Taguchi R. (2010) Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS. J. Biochemistry. 147, 245-256.
  • Endo J., Sano M., Katayama T., Hishiki T., Shinmura K., Morizane S., Matsuhashi T., Katsumata Y., Zhang Y., Ito H., Nagahata Y., Marchitti S., Nishimaki K., Wolf A. M., Nakanishi H., Hattori F., Vasiliou V., Adachi T., Ohsawa I., Taguchi R., Hirabayashi Y., Ohta S., Suematsu M., Ogawa S., Fukuda K. (2009) Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart. Circ. Res. 105, 1118-1127.
  • Yamazaki D., Komazaki S., Nakanishi H., Mishima A., Nishi M., Yazawa M., Yamazaki T., Taguchi R., Takeshima H. (2009) Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation. Development. 136, 2355-2361.
  • Tokudome S., Sano M., Shinmura K., Matsuhashi T., Morizane S., Moriyama H., Tamaki K., Hayashida K., Nakanishi H., Yoshikawa N., Shimizu N., Endo J., Katayama T., Murata M., Yuasa S., Kaneda R., Tomita K., Eguchi N., Urade Y., Asano K., Utsunomiya Y., Suzuki T., Taguchi R., Tanaka H., Fukuda K. (2009) Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. J. Clin. Invest. 119, 1477-1488.
  • Sugiura Y., Konishi Y., Zaima N., Kajihara S., Nakanishi H., Taguchi R., Setou M. (2009) Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry. J. Lipid Res. 50, 1776-1788.
  • Yanagida K., Masago K., Nakanishi H., Kihara Y., Hamano F., Tajima Y., Taguchi R., Shimizu T., Ishii S. (2009) Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J. Biol. Chem. 284, 17731-17741.
  • Nakanishi H., Iida Y., Shimizu T., Taguchi R. (2009) Analysis of oxidized phosphatidylcholines as markers for oxidative stress, using multiple reaction monitoring with theoretically expanded data sets with reversed-phase liquid chromatography/tandem mass spectrometry. J. Chromatogr. B 877, 1366-1374.
  • Hayasaka T., Inoue N., Sugiura Y., Zaima N., Nakanishi H., Ohishi K., Nakanishi S., Naito T., Taguchi R., Setou M. (2008) MALDI-QIT-TOF-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina. Rapid Commun. Mass Spectrom. 22, 3415-3426.
  • Tanaka K., Fukuda R., Ono Y., Eguchi H., Nagasawa S., Nakatani Y., Watanabe H., Nakanishi H., Taguchi R., Ohta A. (2008) Incorporation and remodeling of extracellular phosphatidylcholine with short acyl residues in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1781, 391-399.
  • Oka T., Itoi T., Terada N., Nakanishi H., Taguchi R., Hamaoka K. (2008) Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia. Circ. J. 72, 1359-1366.
  • Hishikawa D., Shindou H., Kobayashi S., Nakanishi H., Taguchi R., Shimizu T. (2008) Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. USA 105, 2830-2835.
  • Yamashita A., Nakanishi H., Suzuki H., Kamata R., Tanaka K., Waku K., Sugiura T. (2007) Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1. Biochim. Biophys. Acta 1771, 1202-1215.
  • Shindou H., Hishikawa D., Nakanishi H., Harayama T., Ishii S., Taguchi R., Shimizu T. (2007) A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. J. Biol. Chem. 282, 6532-6539.
  • Oike H., Wakamori M., Mori Y., Nakanishi H., Taguchi R., Misaka T., Matsumoto I., Abe K. (2006) Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells. Biochim. Biophys. Acta 1761, 1078-1084.
  • Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T. (2006) Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. J. Biol. Chem. 281, 20140-20147.
  • Yamashita A., Kamata R., Kawagishi N., Nakanishi H., Suzuki H., Sugiura T., Waku K. (2005) Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma). J. Biochem. 137, 557-567.
  • Taguchi R., Houjou T., Nakanishi H., Yamazaki T., Ishida M., Imagawa M., Shimizu T. (2005) Focused lipidomics by tandem mass spectrometry. J. Chromatogr. B 823, 26-36.
  • Houjou T., Yamatani K., Nakanishi H., Imagawa M., Shimizu T., Taguchi R. (2004) Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3. Rapid Commun. Mass Spectrom. 18, 3123-3130.
  • Yamashita A., Watanabe M., Sato K., Miyashita T., Nagatsuka T., Kondo H., Kawagishi N., Nakanishi H., Kamata R., Sugiura T., Waku K. (2003) Reverse reaction of lysophosphatidylinositol acyltransferase. Functional reconstitution of coenzyme A-dependent transacylation system. J. Biol. Chem. 278, 30382-30393.

総説(欧文)

  • Taguchi R., Ikeda K., Nakanishi H. (2012) Lipidomics for elucidation of Metabolic Syndrome and related Lipid Metabolic Disorder. Lipidomics, Technologies and Applications. 223-250.
  • Nakanishi H., Ogiso H., Taguchi R. (2009) Quantitative Analysis of Phospholipids by LC-MS for Lipidomics. Method Mol. Biol. 579, 287-313.

総説(邦文)

  • 中西広樹 (2013) 脂質質量分析の高感度化. 遺伝子MOOK 24号 最新生理活性脂質研究 実験手法,基礎的知識とその応用. 77-82.
  • 中西広樹 (2013) 酸性リゾリン脂質を量る. 実験医学別冊 見つける、量る、可視化する!質量分析実験ガイド. 118-123.
  • 中西広樹 (2012) リン脂質およびリン脂質酸化物の分析. 試料分析講座・脂質分析. 101-118.
  • 中西広樹 (2012) MSイメージングによる脂質の局在解析. 試料分析講座・脂質分析. 171-177.
  • 中西広樹 (2011) 酸性リン脂質の高感度分析法とその臨床的有意性. JSB MS Letters・日本医用マススペクトル学会誌. 36, 24-30.
  • 田口良, 中西広樹 (2010) 微量脂質成分測定のための質量分析技術の現状. 実験医学増刊 分子から個体へ深化する脂質生物学. 20-27.
  • 中西広樹, 田口良 (2010) 質量分析計を用いた脂質の組織局在解析. メタボロミクス:その解析技術と臨床・創薬応用研究の最前線. 136-140.
  • 中西広樹, 田口良 (2010) 酸化ストレスマーカーとしての酸化リン脂質のメタボロミクス. メタボロミクス:その解析技術と臨床・創薬応用研究の最前線. 209-213.
  • 中西広樹, 田口良 (2009) 炎症と脂質. SURGERY FRONTIER. 16, 21-28.
  • 佐野元昭, 菱木貴子, 末松誠, 中西広樹, 田口良 (2009) メタボローム. Annual Review 循環器. 25-28.
  • 磯部洋輔, 中西広樹, 田口良, 有田誠 (2008) ω3多価不飽和脂肪酸と炎症のメタボロミクス. 臨床化学. 37, 349-355.
  • 中西広樹, 田口良 (2008) 脂質メタボロミクスとその応用. メタボロミクスの先端技術と応用. 100-110.
  • 菱川大介, 中西広樹, 進藤英雄, 原山武士, 小笠原理恵, 諏訪部章, 田口良, 清水孝雄 (2007) 肺サーファクタント脂質合成酵素の同定. 日本肺サーファクタント・界面医学会雑誌. 38, 50-51.
  • 清水孝雄, 中西広樹, 菱川大介, 原山武士, 進藤英雄, 田口良, 小笠原理恵, 諏訪部章 (2007) 肺サーファクタント脂質の合成機構. 分子呼吸器病. 11, 56-60.

黄 明国 (Huang Mingguo)

原著論文

  • Huang M., Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T. (2013) Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression. Endocr Relat Cancer. 21(1):39-50.
  • Huang M., Narita S., Numakura K., Tsuruta H., Saito M., Inoue T., Horikawa Y., Tsuchiya N., Habuchi T. (2012) A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling. Prostate 72, 1779-1788.
  • Huang M., Narita S., Tsuchiya N., Ma Z., Numakura K., Obara T., Tsuruta H., Saito M., Inoue T., Horikawa Y., Satoh S., Habuchi T. (2011) Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome. Carcinogenesis 32, 1589-1596.
  • Ma Z., Tsuchiya N., Yuasa T., Huang M., Obara T., Narita S., Horikawa Y., Tsuruta H., Saito M., Satoh S., Ogawa O., Habuchi T. (2010) Clinical significance of polymorphism and expression of chromogranin a and endothelin-1 in prostate cancer. J Urol. 184, 1182-1188.
  • Nhien N. T., Huy N. T., Naito M., Oida T., Uyen D. T., Huang M., Kikuchi M., Harada S., Nakayama K., Hirayama K., Kamei K. (2010) Neutralization of toxic haem by Porphyromonas gingivalis haemoglobin receptor. J. Biochem. 147, 317-325.
  • Aramaki T., Ida H., Izumi Y., Fujikawa K., Huang M., Arima K., Tamai M., Kamachi M., Nakamura H., Kawakami A., Origuchi T., Matsuoka N., Eguchi K. (2009) A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis. Mod. Rheumatol. 19, 245-252.
  • Huang M., Ida H., Arima K., Nakamura H., Aramaki T., Fujikawa K., Tamai M., Kamachi M., Kawakami A., Yamasaki H., Origuchi T., Eguchi K. (2007) La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity. Life Sci. 81, 1461-1466.
  • Fujikawa K., Aratake K., Kawakami A., Aramaki T., Iwanaga N., Izumi Y., Arima K., Kamachi M., Tamai M., Huang M., Nakamura H., Nishiura Y., Origuchi T., Ida H., Eguchi K. (2007) Successful treatment of refractory neuro-Behcet's disease with infliximab: a case report to show its efficacy by magnetic resonance imaging, transcranial magnetic stimulation and cytokine profile. Ann. Rheum. Dis. 66, 136-137.
  • Tamai M., Kawakami A., Uetani M., Takao S., Tanaka F., Fujikawa K., Aramaki T., Nakamura H., Iwanaga N., Izumi Y., Arima K., Aratake K., Kamachi M., Huang M., Origuchi T., Ida H., Aoyagi K., Eguchi K. (2007) Bone edema determined by magnetic resonance imaging reflects severe disease status in patients with early-stage rheumatoid arthritis. J. Rheumatol. 34, 2154-2157.
  • Tamai M., Kawakami A., Iwanaga N., Fujikawa K., Tanaka F., Aramaki T., Izumi Y., Aratake K., Arima K., Kamachi M., Nakamura H., Huang M., Ida H., Origuchi T., Eguchi K. (2006) Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. Intern. Med. 45, 795-779.
  • Izumi Y., Ida H., Huang M., Iwanaga N., Tanaka F., Aratake K., Arima K., Tamai M., Kamachi M., Nakamura H., Origuchi T., Kawakami A., Anderson P., Eguchi K. (2006) Characterization of peripheral natural killer cells in primary Sjögren's syndrome: impaired NK cell activity and low NK cell number. J. Lab. Clin. Med. 147, 242-249.
  • Izumi Y., Tominaga M., Iwanaga N., Huang M., Tanaka F., Aratake K., Arima K., Tamai M., Kamachi M., Nakamura H., Ida H., Origuchi T., Kawakami A., Eguchi K. (2006) Twenty-four-week follow-up examination of a leukocytapheresis therapy in rheumatoid arthritis. Mod. Rheumatol. 16, 20-23.
  • Tanaka F., Kawakami A., Iwanaga N., Tamai M., Izumi Y., Aratake K., Arima K., Kamachi M., Nakamura H., Huang M., Ida H., Origuchi T., Eguchi K. (2006) Infliximab is effective for Takayasu arteritis refractory to glucocorticoid and methotrexate. Intern. Med. 45, 313-316.
  • Tamai M., Kawakami A., Tanaka F., Miyashita T., Nakamura H., Iwanaga N., Izumi Y., Arima K., Aratake K., Huang M., Kamachi M., Ida H., Origuchi T., Eguchi K. (2006) Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-gamma through JAK/STAT pathway by translational regulation. J. Lab. Clin. Med. 147, 182-190.
  • Tamai M., Kawakami A., Uetani M., Takao S., Rashid H., Tanaka F., Fujikawa K., Aramaki T., Nakamura H., Iwanaga N., Izumi Y., Arima K., Aratake K., Kamachi M., Huang M., Origuchi T., Ida H., Aoyagi K., Eguchi K. (2006) Early prediction of rheumatoid arthritis by serological variables and magnetic resonance imaging of the wrists and finger joints: results from prospective clinical examination. Ann. Rheum. Dis. 65, 134-135.
  • Tamai M., Kawakami A., Uetani M., Takao S., Tanaka F., Nakamura H., Iwanaga N., Izumi Y., Arima K., Aratake K., Kamachi M., Huang M., Origuchi T., Ida H., Aoyagi K., Eguchi K. (2006) The presence of anti-cyclic citrullinated peptide antibody is associated with magnetic resonance imaging detection of bone marrow oedema in early stage rheumatoid arthritis. Ann. Rheum. Dis. 65, 133-134.
  • Huang M., Ida H., Kamachi M., Iwanaga N., Izumi Y., Tanaka F., Aratake K., Arima K., Tamai M., Hida A., Nakamura H., Origuchi T., Kawakami A., Ogawa N., Sugai S., Utz P. J., Eguchi K. (2005) Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome. Clin. Exp. Immunol. 142, 148-154.
  • Arima K., Origuchi T., Tamai M., Iwanaga N., Izumi Y., Huang M., Tanaka F., Kamachi M., Aratake K., Nakamura H., Ida H., Uetani M., Kawakami A., Eguchi K. (2005) RS3PE syndrome presenting as vascular endothelial growth factor associated disorder. Ann. Rheum. Dis. 64, 1653-1655.
  • Tanaka F., Kawakami A., Tamai M., Nakamura H., Iwanaga N., Izumi Y., Arima K., Aratake K., Huang M., Kamachi M., Ida H., Origuchi T., Eguchi K. (2005) IFN-gamma/JAK/STAT pathway-induced inhibition of DR4 and DR5 expression on endothelial cells is cancelled by cycloheximide-sensitive mechanism: novel finding of cycloheximide-regulating death receptor expression. Int. J. Mol. Med. 15, 833-839.
  • Hida A., Kawakami A., Miyashita T., Yamasaki S., Nakashima K., Tanaka F., Izumi Y., Tamai M., Huang M., Ida H., Nakamura H., Origuchi T., Ueki Y., Eguchi K. (2004) Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis. J. Lab. Clin. Med. 144, 148-155.
  • Ida H., Kawasaki E., Miyashita T., Tanaka F., Kamachi M., Izumi Y., Huang M., Tamai M., Origuchi T., Kawakami A., Migita K., Motomura M., Yoshimura T., Eguchi K. (2004) A novel mutation (T61I) in the gene encoding tumour necrosis factor receptor superfamily 1A (TNFRSF1A) in a Japanese patient with tumour necrosis factor receptor-associated periodic syndrome (TRAPS) associated with systemic lupus erythematosus. Rheumatology 43, 1292-1299.
  • Miyashita T., Kawakami A., Tamai M., Izumi Y., Huang M., Tanaka F., Abiru S., Nakashima K., Iwanaga N., Aratake K., Kamachi M., Arima K., Ida H., Migita K., Origuchi T., Tagashira S., Nishikaku F., Eguchi K. (2003) Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochem. Biophys. Res. Commun. 312, 397-404.
  • Ida H., Nakashima T., Kedersha N. L., Yamasaki S., Huang M., Izumi Y., Miyashita T., Origuchi T., Kawakami A., Migita K., Bird P. I., Anderson P., Eguchi K. (2003) Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death. Eur. J. Immunol. 33, 3284-3292.

木村 洋貴 (Hirotaka Kimura)

原著論文

  • Morishita H., Eguchi S., Kimura H., Sasaki J., Sakamaki Y., Robinson ML., Sasaki T., Mizushima N. (2013) Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem. 288(16):11436-47.
  • Takasuga S., Horie Y., Sasaki J., Sun-Wada GH., Kawamura N., Iizuka R., Mizuno K., Eguchi S., Kofuji S., Kimura H., Yamazaki M., Horie C., Odanaga E., Sato Y., Chida S., Kontani K., Harada A., Katada T., Suzuki A., Wada Y., Ohnishi H., Sasaki T. (2013) Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 110(5):1726-31.
  • Onishi S., Nagashima T., Kimura H., Matsuyama Y., Yoshio T., Minota S. (2010) Systemic lupus erythematosus and Sjögren's syndrome induced in a case by interferon-alpha used for the treatment of hepatitis C. Lupus. 19(6):753-5.
  • Matsuyama Y., Okazaki H., Tamemoto H., Kimura H., Kamata Y., Nagatani K., Nagashima T., Hayakawa M., Iwamoto M., Yoshio T., Tominaga S., Minota S. (2010) Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis. J Rheumatol. 37(1):18-25.
  • Kimura H., Komatsuda A., Sawada K., Mimori A., Baba S., Minota S. (2004) Rapidly progressed secondary amyloidosis in a patient with mixed connective tissue disease. Intern Med. 43(9):878-82.

総説(邦文)

  • 木村洋貴, 小藤智史, 佐々木雄彦 (2013) イノシトールリン脂質とイノシトールリン脂質代謝酵素. 遺伝子医学MOOK 24号 最新生理活性脂質研究 実験手法,基礎的知識とその応用. 218-231.
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